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Cynomolgus monkeys received subcutaneous injections of 1 Magnesium/kg/week Jintrolong® or excipient control once weekly for 26 consecutive weeks, followed by a 26-week recovery period to investigate the possible vacuolation of the CP and the potential for reversibility following recovery in non-human primates treated with Jintrolong®.
No formal hypothesis testing was performed. All AEs were coded using MedDRA. All TEAEs were summarized and presented rein the listings by the number of subjects reporting an event, the percentage of subjects with that Vorstellung, the number of events, the grade, and the relationship to treatment. Percentages were calculated based on the number of subjects jintropin kaufen Weltgesundheitsorganisation received the treatment during the study.
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Deshalb werden unter umständen vielmals vielfältige Dosen in serie, bis zu 1 g dennoch einer Meeting, konsumiert. hierfür spricht die Beobachtung, dass die häufigste „Briefchengröße“ von Mephedron, die bei Sicherstellungen durch die Polizei in dem Vereinigten Monarchie gefunden wurde, fast 750 g beträgt.
Representative histopathological images under the control group and all three doses of the Jintrolong® group are shown hinein Figure S1.
kilometer is the Michaelis constant, and Vmax is the maximum Satz of elimination of the nonlinear pathway. Vc is the volume of Austeilung of the central compartment. fluor stands for bioavailability.
To determine whether the Jintrolong®-dependent vacuolation observed rein CP resulted hinein the alteration of cellular ultrastructure and function of the CP, brain tissue was collected for TEM at the terminal necropsy following the belastung dosing and at the recovery necropsy.
The CP cells of each group under TEM were cubic, with abundant microvilli on the surface, and the tight junctions between the cells and the basement membrane on the bottom were intact.